منابع مشابه
G-protein subunit dissociation is not an integral part of G-protein action.
The concept that a guanosine triphosphate (GTP) binding protein (or G protein) is a transducer of receptor-to-effector signal transduction was formulated in the 1970s for hormonedependent adenylyl cyclase. It has been shown that binding of the hormone to the receptor triggers exchange of guanosine diphosphate (GDP) for GTP on the G protein, thereby converting the G protein from the inactive con...
متن کاملTheoretical study of solvent effects on the thermodynamics of iron(III) [tetrakis(pentafluorophenyl)]porphyrin chloride dissociation.
A quasichemical method that combines ab initio treatment of explicit solvent with dielectric continuum models has been used to study the origin of a strong effect of methanol on the extent of iron(III) [tetrakis(pentafluorophenyl)]porphyrin chloride dissociation in acetonitrile-methanol solutions. It is shown that the dissociation is energetically more favorable in methanol than in acetonitrile...
متن کاملEffects of D2O on the association-dissociation equilibrium in subunit proteins.
Heavy water has been used as a tool to study the role of water in the association-dissociation equilibrium of subunit proteins. In the case of lactate dehydrogenase, DzO was found to stabilize the enzyme at low ionic strength and inhibit subunit interchange between heartand muscle-type enzyme in solution. When frozen, however, subunit interchange occurred to a similar extent in either DzO or Hz...
متن کاملEffects of D , O on the Association - Dissociation Equilibrium in Subunit Proteins
Heavy water has been used as a tool to study the role of water in the association-dissociation equilibrium of subunit proteins. In the case of lactate dehydrogenase, DzO was found to stabilize the enzyme at low ionic strength and inhibit subunit interchange between heartand muscle-type enzyme in solution. When frozen, however, subunit interchange occurred to a similar extent in either DzO or Hz...
متن کاملReceptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation.
Mechanisms for heterotrimeric G protein activation that do not rely on G protein coupled receptor activation are becoming increasingly apparent. We recently identified beta gamma subunit-binding peptides that we proposed bound to a "hot spot" on beta gamma subunits, stimulating G protein dissociation without stimulating nucleotide exchange and activating G protein signaling in intact cells. AGS...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.15.8791